The skin is the body's main barrier against physical insults and microbial pathogens. Diverse and functionally specialized subsets of immune cells in the skin sense and respond to infection or various barrier breaches to activate an immune response and eventually, return to homeostasis. However, deregulated immune responses can also cause skin disorders, such as psoriasis. This Nature Video introduces the environment and key participants in skin immunity during steady-state and disease. Nature has full responsibility for all editorial content, including Nature Video content. This content is editorially independent of sponsors. Sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday. https://go.nature.com/371OcVF

Psoriasis is a chronic inflammatory skin disorder that affects about 2-3% of the population. It is triggered by the immune system, and new insights into the immune processes have thrown up a number of exciting drug targets. This Nature Reviews Drug Discovery animation explores how the immune system goes awry in psoriasis and illustrates how agents that target the cytokine interleukin 17, or other players in the same pathway, are being developed into novel therapies for psoriasis.

This video demonstrates techniques to treat scalp psoriasis, including how to apply treatments to the scalp and how to remove hard scale. Resources: Download an information leaflet: http://www.guysandstthomas.nhs.uk/resources/patient-information/dermatology/treating-scalp-psoriasis.pdf To watch more videos visit our website: www.guysandstthomas.nhs.uk/dermatologyvideos Find out more about our Dermatology services: http://www.guysandstthomas.nhs.uk/our-services/dermatology/overview.aspx

La psoriasis es una enfermedad cutánea que también afecta a los niños. Ángela Hernández Martín nos muestra qué podemos hacer para mejorar el pronóstico de la psoriasis en la infancia.